| abstract |
A polymyxin B component or salts thereof, and a preparation and application thereof. The polymyxin B component includes six α,γ-diaminobutyric acids respectively at positions 1, 3-5 and 8-9, two threonine residues at positions 2 and 10, a phenylalanine residue at position 6 and a leucine residue at position 7 linked in sequence. The threonine residue at position 10 is linked to the α,γ-diaminobutyric acid at position 4 by an amido bond, and the α,γ-diaminobutyric acid at position 1 is linked to 6-methyloctyl-2-enoyl. |