| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a36312675ff15a2e4abbf1069e6ccc9b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6744efafa1451d1e50c710461db12d42 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-6409
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-6409
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02 |
| filingDate |
2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ed1aaf24bdee5318b6a1e9e0e5aed9b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eaed61399e1eb4c1963dd5d15dad0325
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9383a00f80c04a303651238b821dafb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9da87df6c921afe1d887a9e3d06efe43 |
| publicationDate |
2021-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2021180032-A9 |
| titleOfInvention |
Directed evolution of cyp52a12 gene and its use in dicarboxylic acid production |
| abstract |
The invention relates to the directed evolution of CYP52A12 gene and the use thereof for the production of a dicarboxylic acid. In particular, it relates to a method of preparing a long chain dicarboxylic acid producing strain by using directed evolution and homologous recombination, a strain obtained by the method that is capable of producing a long chain dicarboxylic acid under an acidic condition and the use thereof. In particular, the invention relates to a method of preparing a long chain dicarboxylic acid producing strain by directed evolution of CYP52A12 gene and homologous recombination, a strain obtained by the method that is capable of producing a long chain dicarboxylic acid under an acidic condition and the use thereof. By directed evolution of CYP52A12 gene, one strain which has a base mutation at the promoter region of said gene and is capable of producing a long chain dicarboxylic acid under an acidic condition in a shortened fermentation time is screened out in the invention. |
| priorityDate |
2018-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |