| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_57f3e2af72b2933c004ed61dfccaaee1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-581
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5748 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2021-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90b4e8c61ee284ad51e32df2fcbe9e27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0f1fb0dc8687b5762df1251953638e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed6d9899a099b16fd99cedaa56e1397d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0062f417537deb192779718709f66b1d |
| publicationDate |
2021-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2021132075-A1 |
| titleOfInvention |
Materials and methods for detecting fusion proteins |
| abstract |
Methods for histochemical and cytochemical detection of oncogenic rearrangements of genes that result in expression of a fusion protein; materials, kits, and systems useful in such methods; and products resulting from performance of such methods are disclosed herein. At least two protein binding entities are provided: one targeting a portion of a wild-type protein that is retained in a fusion protein and a one targeting a portion of the wild type protein that is lost during the rearrangement that forms the fusion protein. A sample of a tissue suspected of harboring the fusion protein is stained with each of the two entities (either in simplex format or multiplex format), and the staining pattern resulting from binding of the entities is compared to determine the presence or absence of the fusion protein. |
| priorityDate |
2018-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |