| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e8e2915ef1efd66cca94a95aec932485 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-1323
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-105 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0655
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0656 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077 |
| filingDate |
2019-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_881ec787dfdea1576299745237f42321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e8d03f1a4e43a3285be4909b54e5651 |
| publicationDate |
2021-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2021130784-A1 |
| titleOfInvention |
De-differentiated fibroblast-conditioned media for stimulation of disc regeneration |
| abstract |
Embodiments of the disclosure include methods and compositions for disc repair in a mammal using conditioned media (and/or one or more components therefrom) from fibroblasts that have been de-differentiated and cultured optionally with one or more particular conditions and/or compositions. In specific cases, fibroblasts that have been de-differentiated are exposed to hypoxia, histone deacetylase inhibitor(s), DNA methyltransferase inhibitor(s), or a combination thereof, and the conditioned media therefrom is provided in an effective amount to an individual. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112920992-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023136691-A1 |
| priorityDate |
2018-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |