http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021121181-A1

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filingDate 2018-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56fb7c7abe021f2d4f0024817cb2e776
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publicationDate 2021-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2021121181-A1
titleOfInvention Device and method of creating a fluid containment field for administering therapeutics to a nerve
abstract A severed nerve may be surgically rejoined and severed axons fused via sequential administrations of solutions. The solutions may include a priming solution comprising methylene blue in a Ca2+-free saline solution, a fusion solution comprising about 50% (w/w) PEG, and a sealing solution comprising Ca2+-containing saline. The PEG fusion solution may be applied in a nerve treatment device configured to isolate the injured segment of the nerve. The device may include a containment chamber for creating a fluid containment field around the anastomosis. The device may have slits, slots, and/or apertures in opposing endwalls of the device designed to receive the nerve. The device may have an open bath configuration or may include separable lower and upper bodies to create a closed bath configuration. The device may include one or more fluid ports in fluid communication with the containment chamber for introducing and/or removing fluid.
priorityDate 2017-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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