| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8268e39ce70ff2ad19742e2a21d5a90c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c63fcd992f4eb4cc1c1938bfb0c01ae0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-09 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-907
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-90 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate |
2019-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ce28211ecdf28334335e9ec867f7697
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1987ed3b8e1071b62f89f3b43b96d8b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bc7666f3eb2643d3cb9ea771be62c80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_307e048efdcb9194fba8177d2bee990e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_797a83ce724556974861b25259eba340 |
| publicationDate |
2021-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2021115420-A1 |
| titleOfInvention |
Enhanced bcl11a rnp / crispr delivery & editing using a 3xnls-cas9 |
| abstract |
Provided herein are synthetic nucleic acids that encode a CRISPR enzyme fused to a series of nuclear localization signal sequences for the use of altering expression of a gene in a cell. Further provided herein are methods for altering gene expression in a cell comprising introducing the synthetic nucleic acids and a guide RNA, or a polypeptide and a guide RNA into a cell. In certain embodiments the cell is a quiescent cell, for example, a hematopoietic stem cell. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11560555-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022240787-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115716880-A |
| priorityDate |
2018-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |