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filingDate 2020-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2021-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2021101959-A1
titleOfInvention Chimeric antigen receptor
abstract The present invention provides a chimeric antigen recept- or (CAR) comprising: (i) a B cell maturation antigen (BCMA)-binding domain which comprises at least part of a proliferation-inducing ligand (APRIL); (ii) a spacer domain (iii) a transmembrane domain; and (iv) an intracellular T cell signaling domain. The invention also provides the use of such a T-cell expressing such a CAR in the treatment of plasma-cell mediated diseases, such as multiple myeloma.
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