http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021062146-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23a4e0c875bf1ac2b8a3b76517de6c7d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-90 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0697 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-079 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate | 2020-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4ab35bf1d83dfdfa67a3539204954e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_063ccca1939e4593ab8be688b4a1a631 |
| publicationDate | 2021-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2021062146-A1 |
| titleOfInvention | Optimized in vitro cellular system for bbb permeability linked neuroactivity screening |
| abstract | The present disclosure generally relates to a process to prepare a cell culture system that mimics the structure of Blood Brain Barrier (BBB) and are useful to study the functions thereof. In particular, the present invention relates to a direct-contact triculture systems prepared by plating BMECs on a pre-formed lawn of coculture of astrocytes and pericytes on the apical surface of a culture-chamber to achieve a truly direct contact triculture model for BBB. The cell culture systems disclosed herein are optimized using a method called Design of Experiments (DOE) useful for studying the functions of the Blood Brain Barrier and predicting the efficacy and/or potential toxicity of a drug candidate. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114369595-A |
| priorityDate | 2019-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.