abstract |
The present invention belongs to the technical field of new use of medicaments, and particularly relates to use of pantoprazole in the prevention and treatment of liver fibrosis. The pantoprazole inhibits the expression of receptor TGFβR1 for the profibrotic cytokine TGFβ (transforming growth factor β), the activation of hepatic stellate cells and the epithelial-mesenchymal transition in liver, thereby inhibiting the occurrence of liver fibrosis. |