| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0b09584fcdc1896646c7d1863a083d1f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-191
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2018-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f696b9ce00a03f01b5744aad0b775c1b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_241ca9617674f2d629720555dab48049
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf4e5e46572c0a1a3e982936ad35fd20 |
| publicationDate |
2021-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2021023175-A1 |
| titleOfInvention |
Tp53 as biomarker for responsiveness to immunotherapy |
| abstract |
Disclosed herein are methods of treating a subject by an immunotherapy in combination with a low-dose of TNF-a or an LT receptor agonist as well as methods of identifying a cancer patient as having an increased or a reduced likelihood of responding to an immunotherapy by detection of TP53 gene status, in isolation, or in combination with assays for determining the levels of MHC-I and TP53 target genes. Also provided are methods of administering an immunotherapy to select, identified cancer patients. |
| priorityDate |
2017-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |