| abstract |
Provided is a method of producing an amide compound, the method including: obtaining a reaction solution containing an amide compound by bringing a microbial cell containing nitrile hydratase, or a processed product of the microbial cell, into contact with a nitrile compound in an aqueous medium in a first reactor; and causing the obtained reaction solution containing an amide compound to react in a second reactor having a plug-flow region, in which the Reynolds number in the second reactor is controlled to from 5 to 1,000. |