| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate |
2020-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21576a4487ae1da5d45eccf70b5b6e0d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ca8dcb7276051b3ee995359b33dfe75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7941499387af3757e4d369c3b3bf678c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8738403a79dbe58e6cae767ece0bd9dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86745584d5e9a918a0b854db0b7a4a89 |
| publicationDate |
2021-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2021009605-A1 |
| titleOfInvention |
Chromium-mediated coupling and application to the synthesis of halichondrins |
| abstract |
The present invention provides unified synthesis of the C1-C19 building blocks of halichondrins and analogs thereof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hybridized carbon. The provided efficient selective coupling reactions can allow easy access to the C1-C19 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11155562-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11725015-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11548898-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11407762-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11498892-B2 |
| priorityDate |
2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |