| abstract |
The present disclosure is directed to compositions and methods for treating obesity or an inflammatory state present in obese mammals. In general, the methods and compositions disclosed herein utilize previously unrecognized miR regulatory pathways to reduce pro-inflammatory cytokine secretion and promote egress of immune cells from inflammation sites. n An example aspect of the present disclosure includes methods for treating obesity or an inflammatory state in a mammal, the method including delivering a cannabinoid receptor 1 antagonist, a Netrin-1 inhibitor, a miR inhibitor, a miR, a miR mimic, or combinations thereof to the mammal. |