| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eda37409f26cb8e833ba67f2b1bc1fd5 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-05 |
| filingDate |
2020-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae57f434767ec9cc3bb2b1f8eeed5c39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6a7a8395ff54d67d109a8b779b12261
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03ba1f2a5fee5f404b53e43a1ba79fbb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bb711cb47b559ab62c11f8dfcf0af58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61f3f9764364b468bce9088248c50eb1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d1f1be4013b6ce64c1685c839d21594 |
| publicationDate |
2020-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2020397718-A1 |
| titleOfInvention |
Use of hydroxytyrosol acetate in improving function of aortic endothelial cell |
| abstract |
The present disclosure discloses use of hydroxytyrosol acetate in preparation of a medicament for improving aortic endothelial cell function. The hydroxytyrosol acetate is capable of inhibiting an inflammation of aortic endothelial cells caused by a saturated fatty acid, reducing mRNA levels corresponding to matrix metalloproteinase-1 (MMP-1), intercellular adhesion molecule-1 (ICAM-1) and plasma plasminogen activator inhibitor-1 (PAI-1) in aortic endothelial cells and protecting mitochondria from being damaged by inflammation of aortic endothelial cells caused by a saturated fatty acid, preventing the occurrence and development of atherosclerosis by anti-inflammatory and protecting mitochondrial function. |
| priorityDate |
2019-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |