| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_748d59b0cde9710523094becd0c1b701 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0874
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0681
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-163
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2400-0487 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0686
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0679
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502746
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-502761
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0684
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M21-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-06 |
| filingDate |
2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3080fa2aad3224ad33663cea68a0a680
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f14d603ede21b001031c312f4c0182a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_161b67e6d035cfcb8a2ece36df5912eb |
| publicationDate |
2020-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2020392441-A1 |
| titleOfInvention |
Novel microfluidic devices implementing blood and urine circuit for emulating homeostatic microphysiological system |
| abstract |
The present disclosure relates to novel microfluidic devices and their use for operating microphysiological systems. The novel microfluidic devices are particularly useful for pharmacokinetic-pharmacodynamic analysis in the context of ADME(T) profiling. The present disclosure provides novel microfluidic devices comprising a first “blood” circuit with one or more cell culture compartments, and a second “urine” circuit comprising a renal filtration and reabsorption unit, wherein both circuits are connected with each other via the filtration unit and the reabsorption unit. The present disclosure further provides methods, kits and assays implementing the novel microfluidic devices. |
| priorityDate |
2017-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |