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publicationDate 2020-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2020386833-A1
titleOfInvention Nuclear spin hyperpolarization in a porous matrix
abstract A method of enhancing the nuclear spin polarization of target molecules ( 10 ) uses a hyperpolarized source material ( 12 ) that is co-confined with the target molecules ( 10 ) in a porous molecular matrix ( 20 ). The matrix ( 20 ) may be a D 4 R-polysiloxane copolymer such as polyoligosiloxysilicone number two (PSS-2) that has recesses of an appropriate diameter. A source material ( 12 ), such as parahydrogen, is transferred to the matrix ( 20 ) together with the target molecules ( 10 ), and an external pressure is applied to force them into the recesses of the matrix ( 20 ). The nano-confinement of the source material ( 12 ) and target molecules ( 10 ) together enables or enhances a transfer of spin polarization from the source material ( 12 ) to the target molecules ( 10 ). When the target molecules ( 10 ) are removed from the matrix ( 20 ), the enhanced spin polarization greatly enhances the signal strength of the target molecules ( 10 ) in any subsequent magnetic resonance measurement.
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