| abstract |
Sulfonyl hydroxamic acid compounds have the following general formula: n n n n n n n n n n Ring A and B are aryl, heteroaryl, cycloalkyl, fused aryl or fused alkyl group, and R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl, aryl, heteroaryl, halogen, hydroxy, alkoxy, aryloxy, nitro, cyano, ester, or aldehyde. The compounds are HDAC inhibitors. Processes can be used for preparation of these indole-based sulfonyl hydroxamic acid derivatives. |