http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020370120-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f44e3e2c3f3a6412d3f608af7b9bd44 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-166 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6806 |
| filingDate | 2018-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_944476db05f18370983a50d3907341fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_737a8fe32d29e1ff12920d008ec4792c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d692eb624bcf086dfab659b5cf024b8 |
| publicationDate | 2020-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2020370120-A1 |
| titleOfInvention | Reference material for non-invasive prenatal testing and manufacturing method thereof |
| abstract | The invention relates to a method for preparing a simulated maternal cfDNA component for non-invasive prenatal testing, using a DNA fragmentation factor to digest a nucleus for simulating a maternal sample cell line, so as to obtain a simulated maternal cfDNA (short nucleic acid fragment) component. The reference material for non-invasive prenatal testing prepared by mixing different chromosome aneuploid cfDNA fragments with the normal chromosome number cfDNA fragments obtained by the present invention provides a method for manufacturing a reference material for internal quality control and external quality assessment. This method of making a reference material by mixing chromosome aneuploid cfDNA fragments and normal chromosome number cfDNA fragments produced with different enzyme digestions is the first case in the art. This method can also be used to make a series of mixed cfDNA sample reference materials for other noninvasive testing. |
| priorityDate | 2018-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 122.