http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020352880-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd20859e60050bbf7ebad2ba27252123 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-13 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-13 |
| filingDate | 2020-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c8f501bc65351b1b00a1764103ce392 |
| publicationDate | 2020-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2020352880-A1 |
| titleOfInvention | Use of memantine (mem) in prevention and/or treatment of diseases caused by multidrug-resistant and non-resistant bacterial infections |
| abstract | A method for applying memantine (MEM) in preparation of one or more drugs for preventing or treating a disease caused by multidrug-resistant or non-resistant bacterial infections is disclosed. MEM performs an antibacterial or bactericidal action through neutrophils and neutrophil extracellular traps (NETs) to prevent and treat diseases caused by multidrug-resistant or non-resistant bacterial infections. A combined use of MEM and an antibiotic in preparation of drugs for prevention and treatment of diseases caused by multidrug-resistant or non-resistant bacterial infections is also disclosed. By applying cell invasion, cell migration, bacteria-infected mice, Next Generation Sequencing, and other techniques, the antibacterial mechanism of MEM is studied using cell models (in vitro), mouse models (in vivo), and NETs, MEM may effectively block bacteremia/sepsis and diseases caused by multidrug-resistant or non-resistant bacterial infections including bacterial meningitis by inhibition of alpha7 nicotinic acetylcholine receptor (α7nAChR). |
| priorityDate | 2019-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 222.