http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020347091-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d7e2f8fb5650d7d3616661464b67771 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0094 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 |
| filingDate | 2018-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eeb1bef21626a7e7a93fbbf86de0b253 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb6b3f5b0169f0ea2a84cddfe337170e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8370ddd1a63b1f7e45e2870eb8fa71b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c5c634975ef17b315f112e57b39dae8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80bb42a41b434cfdbb2b28a454a06257 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f96748adfa511ea43f81bdb976019afe |
| publicationDate | 2020-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2020347091-A1 |
| titleOfInvention | Method for preparing cholic acid compound |
| abstract | The present application belongs to the field of pharmaceutical chemistry, and relates to a method for preparing a cholic acid compound. Specifically, the present application provides a process for preparing a compound as shown in formula I, comprising subjecting a compound of formula 2 to an oxidization reaction to obtain a compound of formula 3; attaching a trimethylsilyl group to the compound of formula 3 to obtain a compound of formula 4; reacting the compound of formula 4 with acetaldehyde to obtain a compound of formula 5; subjecting the compound of formula 5 to a catalytic hydrogenation reaction to obtain a compound of formula 6; and converting a cyano group of the compound of formula 6 to a carboxyl group to give the compound of formula I. The preparation method has high yield, requires less purification operations, and is suitable for industrial application. |
| priorityDate | 2017-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 269.