| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0249c8c96ed09a989cb0d43c51a3060d |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01184
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01164
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-00 |
| filingDate |
2020-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee9682e1ce9f52bca72ec8a63dba7635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a754dea2216fdad72a655880ae19a998
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_310ee18a1ef0abf136c0b2c6563dda90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e65d5de44930bc69a4b1176c5add126
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_170c03755abb8ef0c5ac9afd4c80d6a2 |
| publicationDate |
2020-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2020340025-A1 |
| titleOfInvention |
Engineered ketoreductase polypeptides |
| abstract |
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine. |
| priorityDate |
2008-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |