abstract |
Provided herein are recombinant masking proteins and recombinant ligand proteins useful in treating cancer, neuro-degenerative disease, and cardiovascular disease. The recombinant masking proteins provided herein may, inter alia, be used as non-covalent masks of antagonists of, for example, cellular growth factors (e.g., TNF) or cell surface proteins (e.g., CTLA-4). |