| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8281ac9f4fb11f15a5da018344453338 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate |
2020-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9451220e6d77d403c33a4455c78bcc27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ebf4eb12fd559cc9534da7a5c40fe02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_351f14989fac122a70ba52944a44db40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e8a3f3873f5921eb9f57df16e0757df |
| publicationDate |
2020-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2020308193-A1 |
| titleOfInvention |
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof |
| abstract |
which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11008304-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10968199-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11466033-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11560368-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10988458-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11345699-B2 |
| priorityDate |
2019-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |