Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2809 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
filingDate |
2020-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b8ff2ebbf97e694bd83a489b2c52c99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f215148442509f7e7d5cf1f1b039d8de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efc13709ac92e16886e8b3b850c57415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_501e2015292806d4427f5e773b014509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ec666a876f9d9e84768f8fb4751693d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0893bd1ea0027d29113a0a7e0b10f0ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5960cc0b34274b0c0b9a91bafd8fadb0 |
publicationDate |
2020-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2020299385-A1 |
titleOfInvention |
Antibodies binding to human and cynomolgus cd3 epsilon |
abstract |
One aspect as reported herein is using a method comprising the step of immunizing an experimental animal, three times with primary cynomolgus PBLs, whereby the PBLs are optionally enriched for T cells without using primary human PBLs as immunogen and without using a denaturing agent for producing a human cynomolgus cross-reactive antibody specifically binding to human CD3 epsilon of SEQ ID NO: 02 and specifically binding to a polypeptide of SEQ ID NO: 01, wherein the human cynomolgus cross-reactive antibody specifically binds to human and cynomolgus T cells, activates human T cells and does not bind to the same epitope as the antibody OKT3, the antibody UCHT1 and/or antibody the SP34. |
priorityDate |
2014-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |