http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020230266-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53301eed6768a437eeb5cfadc640888a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2121-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1069 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1078 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-10 |
| filingDate | 2018-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1600d00682e7c74dd804ff36be330b9d |
| publicationDate | 2020-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2020230266-A1 |
| titleOfInvention | The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy |
| abstract | The present invention is directed to a method for the preparation of a radiolabled conjugate composition comprising Bismuth-213 loaded targeting moieties that have been diluted with cold targeting moieties in a predetermined ratio of amount of cold targeting moieties to amount of Bismuth-213 loaded targeting moieties. Said ratio is determined by determining the amount T of target moieties per diseased cell to be treated, and determining the amount Z of Bismuth-213 atoms needed to kill a diseased cell, and contacting targeting moieties with Bismuth-213 atoms in a ratio of T over Z, to form a conjugate composition with a predetermined ratio of cold targeting moieties and Bismuth-213 loaded targeting moieties. The invention is further directed to a conjugate that can be prepared with the method according to the invention, a pharmaceutical formulation comprising the conjugate according to the invention. |
| priorityDate | 2017-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.