http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020200774-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8b06e78dc15cb7ec2b4e07ca61106d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3332c64284321d704b1a5a78742bfc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-7452 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-325 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-755 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-86 |
| filingDate | 2018-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_791670d14a4c6a846ab33dd547fb56d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0bfa611fdc5be56807259163c5e26e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80ae6d62066dac4349d3f3539f6de345 |
| publicationDate | 2020-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2020200774-A1 |
| titleOfInvention | Methods for identifying whether patients with acute decompensated heart failure (adhf) exhibit a hypercoagulable state |
| abstract | Subjects with heart failure (HF) are at higher risk of developing thrombosis. The inventors thus determined the thrombin generating capacity in patients with acute decompensated heart failure (ADHF). Their prospective study included 34 ADHF patients and 30 control inpatients without HF. Compared to controls, endogenous thrombin potential (ETP) was higher in ADHF patients at admission using platelet-rich plasma and remained increased during the hospitalization period. Soluble markers of endothelial dysfunction including von Willebrand factor, factor VIII and endothelial protein C receptor were higher in ADHF patients at admission. The plasma levels of DNA-histone complexes were elevated significantly in ADHF patients at admission compared to controls. Higher concentrations of annexin-V/tissue factor (TF)-positive eEVs were also found also in ADHF patients at admission compared to controls. The findings demonstrate that methods of determining the thrombin generating capacity in patients with acute decompensated heart failure (ADHF), which combine measurements of endogenous thrombin potential and endothelial dysfunction, are particularly valuable for stratifying the patients and thus for orienting treatments and following-up of the patients. |
| priorityDate | 2017-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 310.