| abstract |
A method of generating an artificial blood vessel organoid, including providing stem cells capable of vascular differentiation, stimulating mesoderm differentiation in the stem cells, stimulating vascular differentiation in the stem cells, developing a cell aggregate from the stem cells, embedding the cell aggregates in a collagenous 3D matrix and stimulating vascular differentiation of the aggregate in the collagenous 3D matrix; organoids obtainable from the method, uses of the methods and organoids in manipulation and screening studied and kits for performing the methods. |