http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020165229-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 |
| filingDate | 2018-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ae772e9faa96530603dc6ab675f3cf2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33b324d2b9d343dfb348c1e7e844c23d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf8bbcfb55c039315ed779c661b2b0b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_382d84dce6300545baf0f3e22c12ffd3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cd232cf14bb078f34f43b3d08113a82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c40b2b72ab23a121c415b5d321d20cff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_298eba204e3d7f4f05fd80fe43423cb8 |
| publicationDate | 2020-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2020165229-A1 |
| titleOfInvention | Polyfluoro-substituted aromatic heterocyclic derivative, pharmaceutical composition containing same, and applications thereof |
| abstract | A polyfluoro-substituted aromatic heterocyclic derivative having the structure as represented by formula I or formula I′, wherein at least one of Ri and R 2 is a fluorine atom, and at least two substituents of Rc, Rd, Re, and Rf are fluorine atoms; and an optical isomer of the derivative, or a pharmaceutically acceptable salt or solvate of the same, or a pharmaceutically acceptable salt or solvate of the optical isomer of the same. A composition containing the polyfluoro-substituted aromatic heterocyclic derivative and an application of the composition in preparing an anti-tumour medicament. The compound provides significant inhibitory effects with respect to Aktl and demonstrates strong proliferation inhibitory activity with respect to tumour cell lines such as an ovarian cancer cell line, a colon cancer cell line, and a prostate cancer cell line. Therefore, the compound may be used as an Akt inhibitor in the medicament for treating a cell proliferation-related solid tumour or blood cancer in the human or animal body. |
| priorityDate | 2017-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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