http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020079903-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a521cfa321c963978df8ae98a84056a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-2606 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-2609 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G65-3312 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-26 |
| filingDate | 2018-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0def362d3379713fcb28cc9bcd2a75e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1c0613b2c5d41601dbf01c4765fd642 |
| publicationDate | 2020-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2020079903-A1 |
| titleOfInvention | Production method of polyoxyethylene derivative having plurality of hydroxyl groups at terminal |
| abstract | A method of producing a polyoxyethylene derivative (1): n n n n n n n n n n where L1 is a divalent linker, X is a functional group capable of reacting with a physiologically active substance, a is 1 or 2, and n is from 11 to 3,650. The method includes Step (A): protecting 4 or 6 hydroxyl groups in a polyhydric alcohol having 5 or 7 hydroxyl groups by cyclic benzylidene acetalization to obtain a compound having a hydroxyl group at a 1-position and a protective group of a cyclic benzylidene acetal structure; Step (B): polymerizing from 11 to 3,650 moles of ethylene oxide to the compound obtained in the step (A) to obtain a polyoxyethylene derivative; Step (C): converting the hydroxyl group at a terminal of the polyoxyethylene derivative to a functional group capable of reacting with a physiologically active substance; and Step (D): deprotecting the protective group of the polyoxyethylene derivative. |
| priorityDate | 2017-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 120.