| abstract |
Methods and compositions for treating or preventing cognitive disorders in mammals, preferably humans, are provided. The methods generally involve activation of the GPR158 signaling pathway involving osteocalcin, e.g., by administratin of undercarboxylated/uncarboxylated osteocalcin. Disorders amenable to treatment by the methods include, but are not limited to, cognitive loss due to neurodegeneration associated with aging, anxiety, depression, memory loss, learning difficulties, and cognitive disorders associated with food deprivation during pregnancy. |