| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3edb9aa141cda1fdc8cb548d0c57f59c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_83eb049447b9e0d9a2cc97639069b6d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_789e25c5612d3c3ec9042472b88d4420
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f206bb00e1c7ad2019f74961875dd5e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61D19-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-061
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5091
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M21-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B10-0058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B10-0096 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B10-00 |
| filingDate |
2019-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d59078e60d47bbe3c8ff4466345e1b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2be7cc6acfc801072731cc1497d4eed4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c00c401113c5b3230495a38f1aeb5b4 |
| publicationDate |
2020-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2020069296-A1 |
| titleOfInvention |
Apparatus and method to isolate sperm based on planar-confined swimming |
| abstract |
The present invention provides a microfluidic device with a confined geometry for isolating a slither-capable subpopulation of sperm which is of higher quality than the raw sperm population. The proposed device isolates slither-capable sperm based on their ability to enter and traverse a confined region where 3D locomotion is restricted. The DNA integrity of the selected sperm was higher than that of the corresponding raw samples by 55% and 122% for donors and patients, respectively. In side-by-side testing this method outperforms current clinical selection methods, density gradient centrifugation and swim-up, as well as sperm selected via general motility. Slithering represents a viable selection mechanism, readily applicable to clinical workflows with the potential to improve outcomes for couples and offspring. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022078144-A1 |
| priorityDate |
2018-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |