| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5095f60dee8e6d7c3faa7cca7b58c08 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-524 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2851
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
2018-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9acfe10eb54c11ffd6106be3ed76c233
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e1dc4460b0bf33d3384081943e08a3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c01b27137fd01328c18993e2b1334d09 |
| publicationDate |
2020-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2020055941-A1 |
| titleOfInvention |
POLYPEPTIDES WITH MUTANT HUMAN IgG4 |
| abstract |
The present invention relates to polypeptides comprising a mutant human IgG 4 , which mutant human IgG 4 is capable of increasing the binding to and activation of immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing FcγRIIb/c (CD32b), but not FcγRIIa (CD32a). More specifically, the invention relates to polypeptides comprising at least one human IgG 4 with a lysine at position 409 (409K), using the EU index according to Kabat et al., which IgG 4 is capable of binding to human CD32b/c with a statistically significant (p=0.05) higher binding affinity than a wild-type human IgG 1 and than a wild-type human IgG 4 , for use in the prevention and/or treatment of an autoimmune disease or allergy, as further defined in the claims. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021188631-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11701387-B2 |
| priorityDate |
2017-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |