http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020048275-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a134bc159d3eb7d6c0a878c985246d8c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-08 |
| filingDate | 2018-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acade984ae060c46ab68797420230f60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7591047eee930cb06dc4119ead27660a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fd91bc37985527f432be66cf4fc1874 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27773beedee388a0410d37b4fce07035 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8abad4c52c60cf4782dc7ed85283832b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ef1d54d762b4ed3f3b0bde922e24bd4 |
| publicationDate | 2020-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2020048275-A1 |
| titleOfInvention | Process for preparing 2-exo-(2-methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane |
| abstract | This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-iso-propyl-7-oxabicyclo[2.2.1]heptane of the formula (I), (I) any one of its individual enantiomers or any non-racemic mixture thereof comprising the steps of (a) deprotonating (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II), (II) any one of its individual enantiomers or any non-racemic mixture thereof in the presence of at least one base of the formula [Mm+]n [An-]m (III) wherein Mm+ represents a m-valent metal cation wherein m is an integer of 1 or 2, and An_ represents a n-valent anion wherein n is an integer of 1 or 2, said base being capable of forming a solvent S1 selected from water, a C1-C4 alkyl alcohol or any combination thereof under the reaction conditions, to form a metal alkoxide or metal alkoxide solvate of the formula (IV), (IV) any one of its individual enantiomers or any non-racemic mixture thereof wherein M m+ , m and the solvent S1 have the same meaning as defined for the base of formula (III), and x denotes a number from 0 to 10, and (b) reacting the metal alkoxide or metal alkoxide solvate of the formula (IV), any of its individual enantiomers or any non-racemic mixture thereof with a 2-Methylbenzyl compound of the formula (V), (V) wherein X is a leaving group, wherein the steps (a) and (b) are conducted in the presence of at least one inert organic solvent S2 and comprise a further step of (c) simultaneously removing the solvent S1 from the reaction mixture. |
| priorityDate | 2017-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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