| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71610c23a5e221cfcf1f5a52e4c7df5e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 |
| filingDate |
2019-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2edfffc53a16c2387ad9f9e22bf73c45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97f9e17d857d507c7aa6b9ed753e928f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da756b89db845be7cb9724811a01d9fa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16bde4ef485e51ec66f8e0e2b6ccedb3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ce4010e5a975742adcf87ef3095b27b |
| publicationDate |
2020-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2020031873-A1 |
| titleOfInvention |
Repurposing cell penetrating peptides and their novel derivatives and iopromide and iodo-aryl carbonates for treatment of senescence-related diseases and disorders |
| abstract |
Methods of use for selected cell penetrating peptides (CPPs) and iopromide repurposed as senolytic agents for treating senescence-associated diseases and disorders by specifically targeting the FoxO4 protein. The diseases and disorders treatable with said repurposed senolytic agents include diseases with inflammatory origin including but not restricted to diabetes, cardiovascular diseases, or pulmonary diseases, including COPD; asthma, emphysema, or breathlessness; renal or hepatic insufficiency, cirrhosis, or osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders; diabetic ulcers; kyphosis; scoliosis; weight loss; hair loss; muscle loss; loss of bone density; frailty and/or reduced fitness; hearing loss such as deafness; or combinations thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115561468-A |
| priorityDate |
2018-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |