| abstract |
Combination therapy with sorafenib or regorafenib and a phosphoramidate prodrug of troxacitabine with the formula: n n n n n n n n n n where Y is C 1 -C 8 straight or branched chain alkyl, X is H, halo, C 3 -C 4 cycloalkyl or C 1 -C 4 alkyl and Z is H or fluoro, or a pharmaceutically acceptable salt thereof, shows surprising utility in the treatment of liver cancer or liver metastasis. |