http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019365660-A1

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filingDate 2018-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_427c3f39aaf5d1e2dfd6042151885d29
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publicationDate 2019-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2019365660-A1
titleOfInvention Nanocapsules and method for manufacturing thereof
abstract A method for manufacturing supported lipid bilayer on a porous silica nanoparticle with a ζ-potential comprised between −10 mV and +10 mV, the method comprising the steps of (a) providing a negatively charged supported lipid bilayer on a porous silica nanoparticle, wherein the negatively charged supported lipid bilayer has a ζ-potential inferior to −15 mV and wherein the negatively charged supported lipid bilayer comprised at least one phospholipid and; (b) adding a formulation of lipids, the lipids being 1,2-dioleoyl-3-trimethylammonium-propane alias DOTAP, cholesterol and at least one lipid different from DOTAP and cholesterol. The method further comprises the step of (c) performing an ultra-sonication for promoting DOTAP incorporation. The method can be supplemented by the step of addition of alginate and the step of cross-linking the alginate. Also a nanocapsule and composition comprising the nanocapsule.
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priorityDate 2017-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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