http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019345457-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb351a5a4e03ee3773bd0df5dbae9ac3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01001 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-12 |
| filingDate | 2019-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92cbaff73fc2da36fa88a164798015ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebc778f953ac8cb96216169e19823fbb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c9c42e457655b8fa00b68273c73de66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33994432ac2f0f50b598fe9ae5305345 |
| publicationDate | 2019-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2019345457-A1 |
| titleOfInvention | Alcohol Dehydrogenase Mutant and Application thereof in Synthesis of Diaryl Chiral Alcohols |
| abstract | The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114591991-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115161297-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10865390-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115011520-A |
| priorityDate | 2018-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 365.