| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c4c4df02281843e773ed6b5e190241c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb89e755ca7d80d8ceac86d3aa231cf4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1063
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-21 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-10 |
| filingDate |
2019-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_256aa9b89949ee2fb49dc2219d4828ed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a3469d4abcb4c23312d0ad56a64244f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e1d7dc86457cae474f22d63d9703d7d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47c2e998b9f8e23c12a770a149deeea6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d30a83980c2a69099fb88657324105b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64b7f23251e54699e3181600ec6b2a7e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90086bb82894f9184d1645c5646adec3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7be6815c679868c2815a84a8ffb60f4a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a96f47e92e0132e051687733dbb80242
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89375b7983f99c1197a234195b0959b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15e27dba5af37bdfc75d73d6af375854
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47809a1f3a1f47444498619160392676 |
| publicationDate |
2019-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2019338017-A1 |
| titleOfInvention |
Monoclonal antibodies directed against trimeric forms of the hiv-1 envelope glycoprotein with broad and potent neutralizing activity |
| abstract |
The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021183556-A1 |
| priorityDate |
2009-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |