| abstract |
Provided are agents that disrupt CRY1-CLOCK-BMAL1 ternary complexes. In certain aspects, the agents bind to the secondary pocket of CRY1 and inhibit interaction between the secondary pocket and the PAS-B domain of CLOCK, to disrupt CRY1-CLOCK-BMAL1 ternary complexes. Also provided are methods for identifying such agents, compositions including such agents, and therapeutic methods employing such agents. |