| abstract |
Modulators of melanocortin receptors (MCR) are provided herein. An MC5R peptide ligand is represented by to Formula 1: n R 1 -Nle 4 -c[Xaa 5 -Yaa 6 -(NMe)D-Nal(2′) 7 -Arg 8 -Trp 9 -(NMe)Zaa 10 ]-R 2 .n n R 1 can be an acetyl, a glycosylated amino acid, —CO—(CH 2 ) n CH 3 , or —CO—(CH 2 ) n CF 3 with n ranging from 1 to 6. R 2 can be an —CONH 2 , —COON, or —CH 2 OH. Xaa, Yaa, and Zaa can each be a natural amino acid or an unnatural amino acid. |