Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b81cb00d46e57ece8758234aca4b0589 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55516 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0012 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
filingDate |
2019-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37b39b42d5a409c3cc546fc98292729e |
publicationDate |
2019-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2019307704-A1 |
titleOfInvention |
Method for enhanced delivery of gene based therapy and vaccination using electroporation |
abstract |
Embodiments of the present invention are generally related to a method of enhancing the transfection efficiency and immunological/pharmacological/therapeutic responses of concurrent gene-based vaccinations or therapies delivered by a wide range of non-viral particles, viral vectors or viral-biomaterials hybrid particles. In particular, embodiments of the present invention are directed to a method of electroporation which enhances the transfection efficiency of RNA replicon loaded lipid-based nanoparticles in-vivo as well as greatly improves immunogen-specific immune responses of such RNA-based vaccinations. This invention also applies to other gene-based vaccination and therapy using non-viral particles, viral based vectors or viral-biomaterials hybrid particles, in conjunction with the said electroporation regimen. |
priorityDate |
2018-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |