http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019300623-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1281b2c3f4387b9b8bcbb641761b291 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3069 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30 |
| filingDate | 2017-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d243c8c94f67320b14d9c71624eeddc5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7e00b62b70e3f930085202f61ab3794 |
| publicationDate | 2019-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2019300623-A1 |
| titleOfInvention | Anti-psma antibodies, uses thereof and conjugates thereof |
| abstract | An antibody or antigen-binding portion thereof which binds to PSMA and comprises a heavy chain variable domain comprising the sequences: n n n n n n (SEQ ID NO: 33) n n n n n n CDR1: EYTIH n n n n n n n (SEQ ID NO: 34) n n n n n n CDR2: NINPNX 1 GGTTYNQKFED n n n n n n n (SEQ ID NO: 35) n n n n n n CDR3: X 2-5 DY n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n n wherein n X 1 is N or Q, and n X 2-5 is YWLF, GWTF or AWTM, n and wherein n if X 2-5 is GWTF or AWTM, the amino acid residue at position H94 in the heavy chain variable region, based on Kabat numbering, is G; and n if X 2-5 is YWLF, the amino acid residue at position H94 in the heavy chain variable region, based on Kabat numbering, is A. n n n The invention also provides compounds that include the antibody or antigen-binding portion thereof, such as conjugates, and their use in the treatment or diagnosis of diseases, in particular cancers, particularly prostate cancer. |
| priorityDate | 2016-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 388.