Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e974c8a148aa6bf505c7e049484889e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4296e3c718c9579ab0ad87c5634f4d47 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A90-10 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06N7-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H50-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H10-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H20-10 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H50-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H20-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H10-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06N7-00 |
filingDate |
2017-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_299b48c296b1db462bb4eb187e8adb17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13e3e5a64f245300c629210cc5bea4d9 |
publicationDate |
2019-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2019287013-A1 |
titleOfInvention |
Methods for determining dosing of a therapeutic agent and related treatments |
abstract |
Provided herein are methods employing a toxicity and efficacy probability interval (TEPI) design for performing a clinical trial, such as a Phase I dose-finding trial. In some embodiments, the methods can be used in the dosing of subjects administered a therapy, such as adoptive cell therapy or other immunotherapy, where safety and efficacy data for a therapeutic agent can be observed in the same timeframe or period. In some embodiments, one or more of or all of the steps of the method occur at an electronic device containing one or more processors and memory, such as implemented by a computer. Also provided are methods of administering a therapeutic agent to a subject in accord with the dosing decisions. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11633426-B2 |
priorityDate |
2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |