http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019210979-A1

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classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F3-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-108
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-02
filingDate 2017-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cece97caeaa8284b5db2b980673046e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6e0990d2cfed7375e3f61b45a44f901
publicationDate 2019-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2019210979-A1
titleOfInvention Method for producing the crystalline form of modification a of calcobutrol
abstract A method is described for production of a high purity compound of the formula (I) in crystalline form of the modification A. In this, starting from high purity gadobutrol, the gadolinium is removed by decomplexation with oxalic acid, and then with a calcium salt the calcium complex is produced in high purity. During the crystallization, a water equivalent of 9-11 weight % is set. The crystalline form of the modification A of the compound of the formula (I) is used in the production of Gadovist.
priorityDate 2016-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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