| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07d5dcbb9f91a44c19e14317e706f590
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_286b9e898c13088362dacd021c0bfc80 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0242
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N1-0226
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2017-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d631b85b33530920e13650081864cbaf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3664f14406a2ea3caf70b949f8adf6f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_214b58f0d1f5b3a4cc1bd7cac8d26044 |
| publicationDate |
2019-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2019183114-A1 |
| titleOfInvention |
Methods and compositions for the preservationof organs |
| abstract |
The present invention relates to methods and compositions for the preservation of organs. The inventors showed that therapeutic intervention during cold ischemia could significantly alter outcome, suggesting active mechanisms taking place. More particularly, the inventors demonstrated that Unfolded Protein Response could be a critical pathway underlying the relationship between cold ischemia time and graft outcome, highlighting the potential for UPR-based therapeutics to improve transplantation efficiency. In particular, the present invention relates to an activator of PERK-ATF4 pathway, an inhibitor of the ATF6 pathway and an inhibitor of the RNase activity of IRE1α for use in the maintain of organ viability during cold ischemia. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112210594-A |
| priorityDate |
2016-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |