| abstract |
The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P 450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure: n n n n n n n n n n The compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions. |