| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd61bc45ac8f65f1146587569adb881e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-46 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-02 |
| filingDate |
2019-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6f5a04d2e274ff8d860d8aeed9194db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73a9e8c22b3bd2e6ab2399dcad8e6999
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdecc9f115b6e0c1f72b7d9c3fcf641d |
| publicationDate |
2019-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2019169119-A1 |
| titleOfInvention |
Process for the preparation of Isosulfan Blue |
| abstract |
Isosulfan blue and processes for the preparation thereof are provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2, 5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10464888-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10752580-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10626086-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10590071-B2 |
| priorityDate |
2007-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |