| abstract |
Disclosed herein are compounds tenvermectin A and B and mixtures of compounds tenvermectin A and B for preventing and treating human or animal parasitic infection. Tenvermectin A and B are macrolide compounds and are produced by genetically engineered bacteria. Tenvermectin A and B are structurally similar to avermectin, ivermectin, milbemycin and emamectin benzoate. The toxicities of tenvermectin A and B are significantly lower than avermectin, ivermectin, milbemycin and emamectin benzoate. The disclosed compounds and mixture of compounds belong to a class of compounds that are useful for killing and eliminating parasites, such as nematodes or arthropods. |