| abstract |
Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen or C 1 -C 6 alkyl; ring A is cyclohexyl or phenyl, optionally substituted; ring B is aryl or a nitrogen-containing heteroaryl, optionally substituted; ring C is phenyl substituted with hydroxyl; each L 1 , L 2 and L 3 is independently C 1 -C 6 alkyl, —CONR 2 — or —CONR 2 —X—C 1 -C 6 alkyl-, each optionally substituted; R 2 is hydrogen or C 1 -C 6 alkyl; and X is a bond or a 5-6 membered heterocycle containing up to 3 ring heteroatoms; and methods of use such as a method for increasing hematopoiesis, for enhancing expansion of a hematopoietic stem cell (HSC), or for inhibiting an interaction between a β-, and/or γ-catenin protein in a cell or a subject by administering a compound of Formula (I) to the subject. |