| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15d42f684941d5b0617ca7764ebdff07 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3233
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3513
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-33 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-01011 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2018-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00c3bbaa0c750380a912d9c838cdd5e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64981a1962d2406a3d03326b1b4cd458
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_281df5e3a0da83436e237939caace464
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a6859460e3f5f9e034fdcf8da684040
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ad2032cb3b86fe2538af93bf68267b6 |
| publicationDate |
2019-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2019117794-A1 |
| titleOfInvention |
Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides |
| abstract |
The present disclosure relates to antisense oligonucleotides (AONs) for modulating the expression of glycogen synthase. AONs of the present disclosure may be useful in treating diseases associated with the modulation of the expression of the enzyme glycogen synthase, such as Pompe disease. Also provided by the present disclosure are compositions comprising AONs, as well as methods of down regulating mRNA coding for glycogen synthase, methods for reducing glycogen synthase in skeletal and cardiac muscle, and methods for treating Pompe disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11713462-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112912399-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021226107-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11236339-B2 |
| priorityDate |
2014-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |